post finasteride syndrome myth

Some men appear initially to tolerate finasteride or dutasteride, with adverse effects arising weeks, months or years after starting the drug. Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics: November 2021. But be careful, friends. HHS Vulnerability Disclosure, Help I think [Propecia] is a potentially dangerous drug. Dont let any man you know take that poison! They have low libido. Statement, via Twitter: November 22, 2022. How do you explain that? My physical and psychological strength is coming back. Yes TRT does seem to help people, but dont solve everything. Keywords: 2022 Mar;8(2):169-170. doi: 10.1159/000518750. Prostatis But that warning isnt prominently featured. Thanks for citing our work [Dr. Faysal]. Adding a warning to pharmaceutical preparations containing the medicinal substance finasteride: Administrative Circular No. @MariaUloko discusses #postfinasteridesyndrome and #pssd. The patient needs to know that, and to be able to say, Im stopping now. BPH? There are currently only 134 reports of Post-5-alpha reductase inhibitor syndrome in FAERS. Side effects thought to be caused by post-finasteride syndrome can be mild or serious. To date, there are no evidence-based effective treatments for PFS. I think androsterone and allopregnanolone, or topical DHEA and progesterone would be good options. Post-finasteride syndrome - PubMed He Became Depressed and His Sex Drive Disappeared. In December 2018, I treated scar (not his real name), a 28-year-old man who was distressed by a number of symptoms associated with finasteride, a drug he had been taking for 12 months for alopecia, as prescribed by his dermatologist. Only individuals who are born with intersex characteristics (hermaphrodites) have low levels of this hormone. Additional side effects of finasteride include: A low DHT state can lead to low dopamine (R), high estrogen (R), high prolactin (due to reduced dopamine), high cortisol (due to reduced clearance) (R), elevated serotonin (due to elevated estrogen and lower dopamine) and hypothyroidism (R). HCG will most likely increase progesterone, but hopefully, it can stimulate 5AR which will increase allopregnanolone. What is Post-Finasteride Syndrome? Yes, in general its safer with less sides, but some people have reported similar side effects as fin. Statement (via Twitter) in response to study titled Long-Term Effects of Finasteride on Prostate Cancer Mortality, January 29, 2019. Maksym et al., Post-finasteride . 8600 Rockville Pike Statement (via Twitter) in response to a study titled Sexual Dysfunction in Men Taking Systemic Dermatologic Medication: A systematic review, Reaction to French medical journal Prescrires annual update of drugs to avoid, I Didnt Want to Go Bald. Epub 2016 Jan 13. The Food and Drug Administration Adverse Event Reporting System (FAERS) was queried to identify medications with the highest frequency of ED adverse event reports from 2010-2020 The top 20 medications with the highest frequency of ED were included in the disproportionality analysis Of these 20 medications, there were 6,142 reports of ED and 5-alpha reductase inhibitors (5-ARIs) accounted for 2,823 (46%) of these reports Seven medications showed significant levels of disproportionate reporting but finasteride and dutasteride had the highest PRRs: 110.03 (103.14-117.39) and 9.40 (7.83-11.05) respectively Physicians and patients should be familiar with medications that are associated with ED. Statement via Twitter, February 10, 2022. People kill themselves after taking [finasteride]I had a colleague who took his own life 15 years ago, so I know it happensand so many people with the same symptoms cant be wrong. Androstanediol glucoronide is a hormone derived from DHT (the hormone inhibited by finasteride). There are some nice recovery stories on TR. Hey Peterson, Skin Appendage Disord. 2023 Feb 2;12(3):653. doi: 10.3390/plants12030653. Post-Finasteride Syndrome (PFS) describes serious neurological, physical and sexual side effects that persist - and commonly develop - after discontinuation of the 5alpha reductase inhibitor finasteride (Propecia, Proscar, generics). In the [long] term, if nothing works out, then go for a hair transplant rather than using Finasteride. A Pill the Doctor Gave Me Destroyed My Life. My sides are: Propecia should have never been approved, and its authorization should be revoked as soon as possible. Responding, via Twitter, to the study Association of 5-Reductase Inhibitors With Dementia, Depression, and Suicide: December 24, 2022. An observational retrospective evaluation of 79 young men with long What Is Post-Finasteride Syndrome? I just picked up Gaba, im assuming this is a good idea? We propose that the Dermatologist Society remove from their guidelines the utilization of finasteride for male pattern hair loss., Sexual and Nonsexual Problems after Finasteride Used for Hair Loss in Young Men: American Society for Mens Health, 2014. Int J Trichology. The effect of finasteride on dry eye disease, Investigative Ophthalmology & Visual Science: June 2022. Course. Doctors & Researchers Speaking Out - The Post-Finasteride Syndrome Zhang JJ, Shi X, Wu T, Zhang MD, Tang J, Yin GM, Long Z, He LY, Qi L, Wang L. Asian J Androl. I cant think of a single patient of mine for whom this drug made the difference in their voiding symptoms. Love the site. A pharmacogenetic survey of androgen receptor (CAG)n and (GGN)n polymorphisms in patients experiencing long term side effects after finasteride discontinuation: International Journal of Biological Markers, Dec. 9, 2014. Havent used this drug in over 7 years of practice except in very rare cases. [E]very day I receive more and more emails from young men whose lives have been changed by finasteride. Some say its all in the mind, a made-up mythbut those who suffer from it surely know theyre not just a hypochondriac. Winston-Salem, NC, Ross J. Baldessarini, MD, Professor of Psychiatry, Quoc-Dien Trinh, MD, Associate Professor of Surgery, Wexner Medical Center, Ohio State University, Govinda Healthcare Medicentre, New Delhi, India, Associate Professor of Urology University of Arizona, University of Miami Miller School of Medicine, Omer Onur Cakir, MD, Department of Urology, Bagcilar Training and Research Hospital, Istanbul, Turkey, Pelita Harapan University Faculty of Medicine, Tangerang, Indonesia, Shelly Gray, PharmD, Shirley & Herb Bridge Endowed Professor, University of Washington School of Pharmacy, YOU & WEE Urologic Surgery & Wellness, Sarasota, FL, Faysal A. Yafi, MD, Associate Professor of Urology, University of California, Irvine Medical Center, Naeem Bhojani, MD, Associate Professor of Urology, Andrology Fellow, Northwestern University, Wedad Saeed Al-Qahtani, Assistant Professor, Naif Arab University for Security Sciences, Riyadh, Saudi Arabia, Abdulmaged M. Traish, PhD, Professor of Biochemistry and Urology, Mark A. Moyad, MD, Director of Preventive & Alternative Medicine, University of Michigan Department of Urology, Abdulilah Al Malik, Regulatory Affairs Director, Saudi Arabia, The Psychiatric Institute, University of Illinois at Chicago, Douglas G. Adler, MD, Professor of Medicine, Medical Director, Sperling Prostate Center, Serrate & Ribal Institute of Urology, Barcelona, Roberto Melcangi, PhD, Head of Neuroendocrinology, Department of Pharmacological and Biomolecular Sciences, Silvia Diviccaro, PhD, Post-Doctoral Fellow, Department of Pharmacological and Biomolecular Sciences, Irwin Goldstein, MD, Clinical Professor of Surgery, University of California at San Diego, Editor-in-Chief, The Journal of Sexual Medicine, Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Krohnstiegcenter Dermatology Center, Hamburg, Germany, Glickman Urological and Kidney Institute, Cleveland Clinic, Hospitalist, UAB Medicine, Birmingham, AL, Andrea Militello, MD, Urologist/Andrologist, Department of Urological, Biomedical and Translational Sciences, Federiciana University, Michael Zitzmann, MD, Andrology Professor, Michael Carmone, MD, Director, Health Research Group, Dietrich von Herrath, MD, Chief Physician, Steven M. Belknap, MD, Research Assistant Professor of Dermatology and Medicine, Northwestern University Feinberg School of Medicine, Marcel Waldinger (1955-2019), MD, PhD, Professor, Department of Pharmacology, Shalendar Bhasin, MD, Professor of Medicine, Alex Tatem, MD, Fellow in Andrology, Male Fertility and Microsurgery, Department of Urology, NYU Grossman School of Medicine, Franois Desgrandchamps, MD, PhD, Chief of Urology, Bernard Bgaud, MD, Professor of Pharmacology, Carla Di Loreto, PhD, Experimental and Clinical Medical Sciences, Nelson Novick, MD, Clinical Professor of Dermatology, Charles J. Ryan, MD, Distinguished Professor of Clinical Medicine and Urology, Jan Tytgat, PhD, Professor of Toxicology and Pharmacology, Erika Cecchin, PhD, Researcher in Clinical and Experimental Pharmacology, Donatella Caruso, PhD, Professor of Pharmacology and Biology, Ralph M Treb, MD, Proefssor of Dermatology, Center for Dermatology and Hair Diseases, Zrich, Sabina Cauci, PhD, Medical and Biological Sciences, Christine A Ganzer, PhD, Assistant Professor, Silvia Giatti, PhD, Pharmacological and Biomolecular Sciences, Bruhin & Associates Psychotherapists, San Diego, California, Professor of Urology, Feinberg School of Medicine, Carlo Trombetta, MD, Head of Department of Urology, Dirk Michielsen, MD, Professor of Urology. We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment.The most frequent sexual symptomswere loss of penis sensitivity (87.3%), decreased ejaculatory force (82.3%), and low penile temperature (78.5%). Diviccaro S, Giatti S, Cioffi L, Falvo E, Herian M, Caruso D, Melcangi RC. Some have petitioned the FDA to include post-finasteride syndrome as a boxed warning. This is the most serious warning given about a medication. To date there are no predictive factors for the risk of development of post-finasteride syndrome and no known treatment for the disorder. Since some of the effects of androgen inhibition cannot be reversed once local androgen levels are re-established, it is temping to speculate that patients could still suffer from adverse sexual effects several months or even permanently after finasteride discontinuation. After 15 years of research i also believe mycotoxins are playing a big role in this, mycotoxins damage the grey matter in your brain which would cause dopamine issues, then a cascade of issues from hpa axis dysfunction, gut issues, hormone issues which wont go away under a complete mycotoxin detox is done. Acta Derm Venereol. I strong[ly] agree with you, using p=0.06 to [say] that no association between suicide and finasteride is a very careless decision. Self-reports provide much of our understanding of post-finasteride . The brain fog has never gone away. What few people know is that there are 5-R and 3 types of 5-R enzymes and that theyre not only involved in the conversion of testosterone to DHT, but also in the: Many of the benefits of testosterone, such as enhanced insulin sensitivity, reduced catabolism, higher dopamine, increased thyroid hormone production, are mediated by DHT, and blocking DHT production prevents those effects/benefits. But check your bilirubin just in case. Healthcare Professionals should carefully monitor patients during treatment with finasteride for psychiatric symptoms (including anxiety, depression and suicidal ideation). Before PFS isnt fun. Accessibility May 21, 2019. Often have low t. Make sure to check dht also! Concern regarding adverse effects of finasteride is increasing. Post-finasteride syndrome is a rare condition that some men may experience after taking finasteride (Proscar, Propecia). PMC The Wonderhair Pill, May 2016. Every dermatologist has their own way of treating the condition. Muscle pain Transdermal substitution of dihydrotestosterone led to an improvement in sexual symptoms in two placebo-controlled studies. Drugs to shrink the prostate (dutasteride, finasteride) shouldnt be used for years on end because it can negatively impact the heart. Dont risk your future children for a little hair. There is not a lot of (if any) scientific evidence to backup this up yet, but that doesn't mean that it's non-existent. 100% agree. Before While the sexual side effects of 5ARIs are well known, there may be persistent genitourinary, physical, psycho-cognitive, anti-androgenic and penile vascular changes after 5ARI discontinuation. Post-Finasteride Syndrome: Legit or Mythic? - YouTube If cortisol is low in blood tests, then you can focus on increasing that, but if cortisol is low in saliva tests but high in blood tests, focus on calming the adrenals. : October 27, 2021, Statement (via Twitter) to research colleague: October 27, 2021. Hi, no I dont have insomnia. Therefore, the effects of a subchronic treatment of finasteride.have been evaluated in male rats. One month after the last treatment.changes in neuroactive steroid levels, steroid receptorsand GABA-A receptor subunitswere detected. The Impact of 5-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health. Avoid all environmental plastics and toxins, Cold and hot exposure, such as swimming in a cold river and doing sauna sessions. No libido 5-R type 1, which creates the neurosteroids 5-DHP and allopregnanolone downregulate the glutamatergic system. eCollection 2021 Oct. Treb RM, Gavazzoni Dias MFR, Dutra Rezende H. Skin Appendage Disord. But unfortunately, in some men, the damage is hardwired. In a key investigation undertaken at Baylor College of Medicine under Dr Mohit Khera, Howell et al. Post-Finasteride Syndrome Exists!! Response (via Twitter) to query by Harrison Kalodimos, MD: What are some atypical medication side effects that you have seen in practice and look out for now on a regular basis? April 1, 2021. Statement (via Twitter) in response to Jagan Kansal, MDs tweet, Thoughts on propecia in young guys causing decreased libido, possibly permanent? November 6, 2020. Yuck. Thanks. Although, they would like you to believe testosterone replacement is the only solution to make a full recovery. Differential Gene Expression in Post-Finasteride Syndrome Patients Bookshelf Androsterone both allopregnanolone and androsterone are potent GABA agonists, so might substitute to a degree for each other. Propecia was approved in 1997 as a solution to slow male pattern baldness. Some people actually report dramatic improvements in their symptoms after starting a certain SSRI. 2012 Nov;9(11):2927-32. doi: 10.1111/j.1743-6109.2012.02846.x. Serious Side Effects: Post Finasteride Syndrome In addition, there is a recognized conglomerate of sexual side effects accompanied by neuropsychiatric effects including depression that have been grouped into a term known as post-finasteride syndrome. Pills for Hair Growth: YouTube, June 2022. So thats all gone in many men, just because of finasteride. Well, SSRI drugs almost never only inhibit the reuptake of serotonin, but they often also increase allopregnanolone, decrease serotonin receptor sensitivity, block certain serotonin receptors, release dopamine and histamine, etc. You have to choose between hair and sex drive and your personality and your marriage or your partnership Ive tried giving testosterone to patients who are on finasteride at the same time. (A call with me is usually $200, but since this is your first call, I've got you covered.). You must know that this molecule, finasteride, has been the subject of more than 2,600 scientific articles found in trustworthy databases. Topical progesterone the skin is rich in 5-AR, so applying progesterone to the skin should increase allopregnanolone. Emerging post-marketing reports of persistent depression and sexual side effects have led to growing concerns about the safety of 5-reductase inhibitors and prompted product labeling changes in many regulatory jurisdictions. Baldness Medication Can Cause Permanent Erection Problems (English translation): De Volkskrant, February 15, 2019. The authors declare no conflicts of interest. MeSH : June 21, 2022. Many clinicians are unaware of the scope of the persistent physical and psychological adverse effects of finasteride while it is in usage and despite its discontinuation. In my clinical experience, the length of time on the medication does not correlate with the severity or duration of the side effects. Brian fog Then, when people are coming back and saying they have libido issues, those are relevant. Chronic insomnia , I am now taking Trazodone which helps me get to sleep, I also have myoclonic twitches and brain zaps while trying to fall asleep and my auditory system is super sensitive any small noise at night makes my me jump even when wearing ear plugs. Post-finasteride syndrome (PFS) has been claimed to occur in men who have taken oral finasteride to treat either hair loss or benign prostatic hyperplasia, independent of age, dosage, or indication. The .gov means its official. How Avodart and Proscar Affect Libido: Prostate Cancer Research Institute, May 3, 2021. My yardstick for treating any patient is, what would I do if this were my own son? Thus, it is inappropriate to dismiss this condition. Bone pain Reaction to French medical journal Prescrires annual update of drugs to avoid, March 18, 2021. 2022 Oct 27;10(11):2725. doi: 10.3390/biomedicines10112725. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women, Post-finasteride syndrome: a surmountable challenge for clinicians, Direct Healthcare Professional Communication letter, BioBalance Healthcast: The Ugly Truth About Finasteride. From 50UI per day. In addition, it is imperative to study in detail the molecular mechanisms that cause this condition, trying to identify a possible genetic predisposition, in order to limit the burden of PFS. Curr Urol Rep. 2018 Jun 16;19(8):65. doi: 10.1007/s11934-018-0814-z. Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia: Journal of Sexual Medicine, November 2016. You definitely want high dopamine and low serotonin to optimize cognition and mindset. Considering the thousands of sufferers who already have PFS, the scientific world immediately needs to conduct more research to determine how to effectively treat this horrible symptom complex. Discontinuation of the drug should actually make the hormones work again.but apparently, something breaks down in some men, in the prostate, in the brain, in the whole organism. Our analysis indicates that, nonetheless, [PFS] is clearly a problem that is important to the general public that warrants intervention. I didnt believe it either, until 10 years ago, when I started seeing more men with PFS I advise you once again to never use [finasteride] to treat hair loss. Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma: Journal of Steroid Biochemistry and Molecular Biology, February 2015. Federal government websites often end in .gov or .mil. wow very helpful articular and explains my symptoms exactly. Find support. Please enable it to take advantage of the complete set of features! 2022 Oct;11(10):1452-1457. doi: 10.21037/tau-22-92. Now two months after stopping Dudasteride, my twitches and brain zaps are now greatly diminshed, insomnia is still a problem though. Epub 2020 Jun 26. Response (via Twitter) to Rachel S. Rubin, MD, vis-a-vis the clinical study titled Post-finasteride syndrome: An emerging clinical problem, January 2, 2020. Thanks for the positive feedback and Im glad its helpful. government site. Accordingly, Health Canada and the UAE Ministry of Health recommend that companies that produce products containing [finasteride] add the above-mentioned warning to the internal leaflet of their products. I recovered and I hope all of you suffering from PFS recover too. Stop finasteride: 45.6% 2021 Nov;7(6):524-526. doi: 10.1159/000514365. Lasting dysfunctions after use of finasteride or dutasteride So lets discuss what the drug, finasteride, does in the first place. Do Anti-Baldness Remedies Make You Impotent? [O]ur results showed that [finasteride] treatment affected the expression of a number of accumbal proteins involved in key functional processes, such as regulation of GABAergic neurotransmission, as well as steroid and pyrimidine metabolism. Its always been a question in my mind: Was this a lingering drug effect, or are there other factors coming into play? It is essentially a masculinizing hormone and may have an effect on sexuality Women present low levels of Androstanediol glucoronide naturally, since they produce little testosterone. But I am actually not interested in you. We are certainly very cautious, because we see the side effects [of finasteride]. A low estimated prevalence of PFS cannot be an excuse for nonvigilance since the drug is used by millions of relatively young and healthy individuals.". Post-finasteride syndrome is a serious state of permanent sexual, mental and physical side effects which do not resolve after quitting the drug It is also surmised by the few specialists in the medical field that a type of receptor or brain damage has occurred.Men suffering from PFS are plagued with many physical, mental, and emotional symptoms that have led to long-term depression, marital problems and divorce, and now several reported cases of suicide. They have flat emotions. Chiriac G, Cauci S, Mazzon G, Trombetta C. Andrology. Agreed. Even if the incidence of persistent sexual adverse events is 3% to 5%, which may be viewed as a small number, approximately 900,000 to 1.5 million men would suffer persistent sexual and psychiatric adverse events. It is not known why some men are susceptible to the potential adverse effects of finasteride, while othersthe majorityare not affected.Further research is needed on who is susceptible to the persistent, adverse side-effects of finasteride and on the underlying mechanisms of the medication. Indian J Plast Surg. FDA is concerned that use of finasteride by pediatric patients may pose long-term safety risks regarding growth, development and sexual function. Conclusion: This study showed that short and/or long (CAG)n and (GGN)n repeats had different frequencies according to symptoms reported by patients with PFS, likely reflecting the vast array of genes modulated by the AR [and] a U-curvilinear profile of (CAG)n repeats for skin dryness symptoms, where the two extremes exhibited a worse condition than medium repeats. Post-finasteride syndrome is characterized by persistent sexual, physical, and mental health side effects that continue even after stopping the medication. You wipe a drug off the earth mine is finasteride Go! Indeed, delineating the pathophysiological mechanisms underlying PFS will be of paramount importance to the understanding of this syndrome and to development of potential novel therapeutic modalities. These serious adverse side effects include persistent or irreversible sexual, neurological, physical and mental side effects. Unable to load your collection due to an error, Unable to load your delegates due to an error. Low levels of these hormones increase glutamate and may account for the appearance of behavioural disorders such as anxiety, aggression, and cognitive dysfunction. Post-Finasteride Syndrome: An Induced Delusional Disorder with the A few top supplements to lower estrogen include: For more a comprehensive guides on lowering estrogen, check out this article: Dopamine, testosterone and DHT go hand in hand with improving cognitive function, creativity, determination, positivity, problem-solving, euphoria, etc. [T]here has been a Red Hand Letter for this drug since 2018. Hi man, what have you done so far that helped you to 80% recovery? Keep sexual side effects in mind! I am quite distressed atm and hope this is not permanent and everyone is telling me Im just hypochondriac but I know my sexual function is inhibited for the time being. Physicians treating male pattern hair loss should discuss with patients the potential risk of adverse events with finasteride. Aim: To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. 5-reduced steroids are significantly increased in a hyperthyroid state. Increasing carbon dioxide production. Men reporting Post-Finasteride Syndrome experience side effects that persist after stopping finasteride or other 5-alpha reductase inhibitors. I feel deeply for all my balding brothers out there who are suffering from this poison. Medications Most Commonly Associated with Erectile Dysfunction: The Journal of Urology, May 15, 2022. But Nobody Warned Me about Finasteride! Hi, being a young guy with PFS since 8 months this article has been very helpful to furthermore understand what is possibly going on, so thank you. Topical TRT will increase DHT even more. Finasteride Reviews & Ratings - Drugs.com Episode 18. My goal is to get off Trazodone as quickly as possible, any recomendationsto further aid with insomnia ? Post-Finasteride Syndrome: Efforts to explain persistent symptoms are undermined by poor long term data on harms: The BMJ, August 9, 2019. Successful Finasteride Treatment Can Lead to Permanent Problems: Deutsche Apotheker Zeitung, April 2018. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. BioBalance Healthcast: The Ugly Truth About Finasteride, June 7, 2021. Post finasteride syndrome is real. Organizations such as the Post-Finasteride Syndrome . 2016 Mar;4(2):245-50. doi: 10.1111/andr.12147. Do explosive exercises, such as uphill sprints, muscle-ups, jump squats, burpees, etc. Case report: a study of the clinical characteristics and genetic variants of post-finasteride syndrome patients.
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