HysterSisters.com is a massive online community with over 475,000 members and over 5 million posts. Before Render date: 2023-05-01T15:29:35.649Z 6rT(NQoQar?S<. Emerg. Uncommonly, patients present with allergic reactions to the adhesive compounds; these allergies are often misdiagnosed as cellulitis or another infectious process, and are incorrectly treated. Salazar, Peggy E. Open 6, e1841 (2018). MeSH BMJ Open 6, e009257 (2016). Park, Y. H., Song, J. H., Choi, G. W. & Kim, H. J. Objectives, Submission, Review, & Contact dermatitis, patch testing, and allergen avoidance. Ophthalmology 110, 291298 (2003). 0000007745 00000 n Perry AW, Sosin M (2009) Severe allergic reaction to Dermabond. Last menstrual period occurred at 42 years old. Having any kind of surgery means being exposed to many materials and medications. 0000068378 00000 n and Kim, Roderick Y. In rare cases, scratching or otherwise irritating the rash can result in a skin infection. However, because n-butyl cyanoacrylate remains a viable option as a topical skin adhesive, the results of this study would be helpful for surgeons planning to use n-butyl cyanoacrylate topical skin adhesive. That's a shame about being allergic to the dermabond! Nunley, Julia 187, 238248 (2004). Please enable it to take advantage of the complete set of features! Wright JD, Herzog TJ, Tsui J, Ananth CV, Lewin SN, et al. Don't add any creams to what you were prescribed without checking with your doctor. Yoshimura, Kotaro Fibrin glue versus N-butyl-2-cyanoacrylate in corneal perforations. The patient's husband eventually excised the residual Dermabond and reclosed the wound. The increased prevalence of keloids in atopic dermatitis patients with allergic comorbidities: a nationwide retrospective cohort study, Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis, Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions, Meta-analysis of the efficacy of preoperative skin preparation with alcoholic chlorhexidine compared to povidone iodine in orthopedic surgery, Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers, Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice, Bacterial sensitivity to chlorhexidine and povidone-iodine antiseptics over time: a systematic review and meta-analysis of human-derived data, http://creativecommons.org/licenses/by/4.0/, Contact Dermatitis in the Inpatient Hospital Settingan Updated Review of the Literature. Park, Y.H., Choi, J.S., Choi, J.W. 0000053601 00000 n Ricci JA, Parekh NN, Desai NS. Work as a cosmetician with regular exposure to cyanoacrylate-based eyelash extension glue has also been linked to occupational asthma and allergic rhinitis [27]. Dermabond - allergic reaction Need Answers? Wound complications after 2-octyl skin closure systems for total joint arthroplasty. In addition, since the agent used for postoperative wound dressing was the same as that used for preoperative skin preparation, the area of the rash or erythema would have been more extensive than that of the topical skin adhesive if the patient was allergic to the dressing agent. Here we report a case of allergic reaction secondary to use of Dermabond at Mount Sinai Hospital in New York, NY. Therefore, we thought that although females generally develop ACD more often than males, there is no sex difference in ACD that occurs after using 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. } J. Arthroplasty 28, 553556 (2013). 2014; 29 (5): 1-3. Last medically reviewed on August 30, 2021. The findings of this study showed that the incidence of ACD was 2.7% in 2-octyl cyanoacrylate and 2.2% in n-butyl cyanoacrylate, but none of the variables were found to increase the risk of ACD. Leggat, P. A., Smith, D. R. & Kedjarune, U. Surgical applications of cyanoacrylate adhesives: A review of toxicity. The time was significantly different between the two groups (P < .01). The site is secure. 18, 1927 (2004). Tissue adhesives for closure of surgical incisions. I also found that taking liquid Benedryl before bed really helped too. Would you like email updates of new search results? 0000010468 00000 n Our case, and the cases reviewed here, highlight the usual temporal presentation of allergic reaction to Dermabond. official website and that any information you provide is encrypted Occupational asthma has also been linked to exposure to cyanoacrylate adhesives used to affix sculpted acrylic artificial nails in beauty salons [28]. Of note, the patient underwent a tubal ligation one year before this procedure. Conclusions: 2467926 and 2467927. 0000062096 00000 n Her wounds were closed with Vicryl sutures (Ethicon), deep dermal polydioxanone sutures (Ethicon), key sutures with Prolene (Ethicon), and Dermabond on the skin. 2nd ed. Background: The clinical characteristics of patients with allergic contact dermatitis (ACD) due to a skin adhesive containing 2-octyl cyanoacrylate, Dermabond, have not yet been elucidated. Coover and was marketed by the Eastman Kodak Company in 1958 as formulation Eastman 910 [9]. 10 Replies, Last Reply 12-06-2010, Started By anne17, 10 Replies, Last Reply 03-30-2010, Started By akabezer, 4 Replies, Last Reply 04-02-2007, Started By sdloxham, 10 Replies, Last Reply 04-19-2006, Started By rockin robin, 5 Replies, Last Reply 10-23-2005, Started By ENDH8, 1 Reply, Last Reply 02-13-2005, Started By kelter, 2 Replies, Last Reply 11-23-2004, Started By Northern Angel, 4 Replies, Last Reply 08-08-2004, Started By chudgins, 7 Replies, Last Reply 10-14-2003, Started By audrey1, 4 Replies, Last Reply 03-02-2003, Started By texaggie, 3 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 2 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 10 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 1 Reply, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 16 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause, 4 Replies, No Uterus - No Ovaries - Yes HRT - Surgical Menopause. An official website of the United States government. 0000056163 00000 n w5P 6 5N,i5E$3011aeax0d2b fc2ba41q?g+3dQ2 /:+c=2F-x..FDtT81a.Q|,/1E0|b Michalowitz, A., Comrie, R., Nicholas, C., Wagner, M. & Kehoe, J. For wound dehiscence, adhesive tape was applied to the margins of the wound. Abdomen of 63-year-old patient on post-operative day 7 with sudden onset erythema and pruritus surrounding the umbilical, left upper abdominal, left lower abdominal and right lower abdominal 5-mm trocar sites. Use of cyanoacrylates for adhesive applications dates to their initial synthesis and patent in 1949 [8]. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. The patient was advised to remove the skin adhesive with petroleum jelly and acetone. In this retrospective cohort study, we evaluated the incidence and characteristics of contact dermatitis (type IV hypersensitivity reaction) post application of Dermabond (Trade name PRINEO . First, patch tests were not conducted on all suspected patients to diagnose ACD, so the accuracy of the diagnosis could be doubted. Dermatologist evaluation confirmed the suspicion of an allergic reaction to Dermabond and recommended application of a thin topical layer of hydrocortisone 1% to affected areas 2-4 times per day. ct1qJq7?03Y1n`UA4/EQfcs&80.e` Treatment for contact dermatitis is generally very simple. J. Vasc. Of the 1145 patients included in the study, 32 (2.8%) patients were referred to dermatologists for suspected ACD after the use of a topical skin adhesive in the foot and ankle surgery, and 29 (2.5%) patients were diagnosed with ACD. researchers, each embracing the concept that basic knowledge can foster Webster RG Jr, Slansky HH, Refojo MF, Boruchoff SA, Dohlman CH (1968) The use of adhesive for the closure of corneal perforations. Patients were followed up between the first and second week after surgery, and surgical wounds were inspected by orthopedic surgeons. As these values did not differ from those of all patients with possible risk factors (p=0.857 and 0.955, respectively), we concluded that previously known risk factors for type IV hypersensitivity did not significantly affect the incidence of ACD in topical skin adhesives. 2020. However, in this study, the use of topical skin adhesive did not differ by sex, and the incidence of ACD was also not affected by sex. Her husband, a physician, feared infection and prescribed 1 g of intramuscular ceftriaxone (Rocephin; Roche Laboratories, Nutley, NJ) and oral sulfamethoxazole/trimethoprim (Bactrim DS; Roche Laboratories). Here's what may be causing them and what you can do to ease your symptoms. National Library of Medicine European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice. Y.H.P. Contact Dermatitis. Dermatitis 25, 99100 (2014). Singer, A. J. Hysterectomy Recovery (post hysterectomy). Figure 2. PubMed Sato M, Inomata N, Aihara M. A case of contact dermatitis syndrome caused by Dermabond, followed by contact dermatitis caused by false eyelash glue and Aron alpha glue: possibility of cross-reactions among cyanoacrylates. Skin hypersensitivity following application of tissue adhesive (2-octyl cyanoacrylate). I had a horrible reaction too. While your rash may resolve quickly, you may need to change bandages or medications your doctor has prescribed. Topical skin adhesives were applied according to the instruction manual of each product. The next morning, with worsening erythema and itching, she was seen in the emergency room by the surgeon. 5, 101105 (2020). The surgeon and infectious disease physician agreed that her erythema was an allergic reaction to the Dermabond. A methylprednisolone dose pack was prescribed (Medrol dose pack, Pfizer Inc., New York). Sheikh, Mohammad Tafazul What is the outlook if you have a post-surgical rash? Dowson, C. C., Gilliam, A. D., Speake, W. J., Lobo, D. N. & Beckingham, I. J. Disclaimer. sharing sensitive information, make sure youre on a federal endstream endobj 135 0 obj <>stream to worldwide, enabling them to utilize available resources effectively. To date, ACD to topical skin adhesives has been continuously reported in case reports of sporadic events, but systematic studies on their incidence and risk factors have been limited. It was so itchy! 0000031623 00000 n If things get worse, tell your doctor - and also if your symptoms haven't subsided after 3 weeks. Jock itch and related conditions can cause discomfort and itchy, irritated skin. Singer, A. J. et al. 2016 Mar-Apr;27(2):75-6. doi: 10.1097/DER.0000000000000163. 16 September 2014. Patch Testing Ingredients of Dermabond and Other Cyanoacrylate-Containing Adhesives. Eczema types: Contact dermatitis diagnosis and treatment. Bhargava K, White JM, White IR (2012) Eyelid allergic contact dermatitis caused by ethyl cyanoacrylate-containing eyelash adhesive. Except for Nakagawa et al., our incidence of 2.7% is somewhat higher than the previously reported incidence, but studies to date alone cannot clarify whether this is due to the difference in application site or patient demographics. Wound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. Dermabond was applied after her subcuticular suture closure. and transmitted securely. Register Clinical Trials, Guidelines for The use of Dermabond as the first choice for closing surgical wounds will only increase with the increasing number of gynaecologic surgeries being performed robotically and laparoscopically. 0000012232 00000 n Did you know that treatment with milk, lemon juice or. J.S.C. eCollection 2021. We identified patients with positive patch test results for Dermabond and evaluated their results concerning (meth)acrylates and ethyl cyanoacrylate adhesive. Hysterectomy is one the most commonly performed surgeries in women in the United States. The patch test was selectively performed when the lesions exhibited atypical features or a topical skin adhesive was not suspected to be the cause of dermatitis. This addition is the most recent expansion of traditional skin wound closure techniques such as suture, staple, and adhesive tape approximation [4]. and transmitted securely. Allergic Contact Dermatitis after Repeated Exposure to Dermabond (TM.) Studies investigating the inherent risk factors of ACD found that females have a higher susceptibility to ACD than males and due to the difference in hormonal influences and exposure mode to the allergen22. %PDF-1.7 % Post-surgery contact dermatitis is generally caused by an allergen or something that irritates your skin. Pruritus will begin at the incision sites around post-operative day 3 and continue until development of visually apparent erythematous wheals surrounding each site around post-operative day 7. After DERMABOND PRINEO System is applied, how will the surgeon assess whether the wound is healing 6, 171177 (1999). Uda, Hirokazu But is jock itch contagious? Background: PMC aaaai.org/conditions-treatments/allergies/anaphylaxis, nyulangone.org/conditions/eczema-dermatitis/treatments/at-home-therapies-for-eczema-dermatitis, ncbi.nlm.nih.gov/pmc/articles/PMC6170075/, nationaleczema.org/eczema/types-of-eczema/contact-dermatitis/, aaaai.org/Tools-for-the-Public/Allergy,-Asthma-Immunology-Glossary/Contact-Dermatitis-Defined, aaaai.org/tools-for-the-public/conditions-library/allergies/contact-dermatitis-overview, nyulangone.org/conditions/eczema-dermatitis/diagnosis, aad.org/public/diseases/eczema/types/contact-dermatitis/treatment, nyulangone.org/conditions/eczema-dermatitis/treatments/medication-for-eczema-dermatitis, aad.org/public/diseases/eczema/types/contact-dermatitis/patch-testing-rash, aad.org/public/everyday-care/itchy-skin/rash/rash-101, aaaai.org/Tools-for-the-Public/Drug-Guide/Topical-Ointments-Creams, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. Published online by Cambridge University Press: The https:// ensures that you are connecting to the It will end, though. Healthline Media does not provide medical advice, diagnosis, or treatment. Positive reactions to ethyl cyanoacrylate adhesive (Aron Alpha) occurred in seven of nine patients, to ethyl cyanoacrylate 10% pet. 39, 13751405 (2014). volume11, Articlenumber:23762 (2021) Rash 101 in adults: When to seek medical treatment. On day 6, the patient noted an enlarging nonpainful but significantly pruritic rash along the incision lines. Infect. HHS Vulnerability Disclosure, Help I used hydrocortisone cream and pure aloe gel on the red patches. publishing polices. El-Gazzar, Y. et al. 2020 Nov 1;43(6):e515-e522. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. 1)17,19. Ardis AE (1949) US patent nos. Surgical wound closure by staples or sutures? 0000056539 00000 n Article Close this message to accept cookies or find out how to manage your cookie settings. Am. PMC Latex allergies arise from an allergic reaction to products containing latex. There has never been a reported case resulting from gynaecologic surgery until now. 0000052838 00000 n 0000059825 00000 n Google Scholar. J. ~)4@ @ u~_/eo/Zi}M^_3AAgFqf Larger molecular weight monomers, such as the 2-octyl cyanoacrylate formulation used in Dermabond, have proven to be less histotoxic. Generally, very few complications are associated with Dermabond and are usually related to application techniques. 8 Days Post Hysterectomy Allergic Reaction to Dermabond - Help. Wright JD, Ananth CV, Lewin SN, Burke WM, Lu YS, et al. After that, a standard absorbent dressing was applied and changed on the second day after surgery. These materials can irritate the skin or cause an allergic reaction in some people. 2020 John Wiley & Sons A/S . doi: 10.7759/cureus.14090. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Emerg. ), Use of 2-octyl-cyanoacrylate skin adhesive (Dermabond) for wound closure following reduction mammaplasty: a prospective, randomized intervention study, A prospective comparison of octyl-2-cyanoacrylate and suture in standardized facial wounds, Allergic contact dermatitis to Dermabond after orthopaedic joint replacement, Allergic contact dermatitis caused by topical 2-octyl-cyanoacrylate, Allergic contact dermatitis after postsurgical repair with 2-octylcyanoacrylate, Foreign body reaction after usage of tissue adhesives for skin closure: a case report and review of the literature, 10 years of patch testing with the (meth)acrylate series, Ectopic contact dermatitis from ethyl cyanoacrylate instant adhesives, Contact dermatitis to ethyl-cyanoacrylate-containing glue, http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4233b2_01.pdf. Dermabond () surgical glue had been applied to the skin at wound closure; the glue residue remained on the skin for several days. Parkerson, Jamie 7 status post total laparoscopic hysterectomy and bilateral salpingo-oophorectomy with sudden onset of erythema and pruritus around all four port site incisions (Figure 1). 0000009330 00000 n (n.d.). 0000060206 00000 n Its medical use quickly spread and interestingly, the first reported use of a cyanoacrylate tissue adhesive on the human eye occurred in 1968 [11]. 156, 577578 (2021). ~%_W+`Su3-x3LX8pg u Contact Dermatitis and Medical Adhesives: A Review. A 36-year-old white woman on postoperative day four. The number is still staggering even though some estimate that the number of hysterectomies has been steadily declining over the last decade from a peak of 681,234 performed in 2002 to 433,621 cases reported in 2010. They note the reaction resolved with administration of topical corticosteroids, obviating the need to remove the Dermabond. The National Eczema Association says that people who have allergies to any of those things or if the skin is irritated by them may end up with a rash called contact dermatitis. 0000002325 00000 n Acad. Skin inflammation and pruritus abated completely within two days. Off-label medical use was widespread in many surgical specialties and dentistry by the 1980s especially throughout Europe. Durando, D. et al. Medicine 99, e20573 (2020). Desai, Naman S. Recently, we reported a 14 percent incidence of allergic reaction to the cyanoacrylate-based surgical glue Dermabond (Ethicon, Inc., Somerville, N.J.). There are two main causes of this type of rash: Contact your doctor immediately if your wound or the area around it becomes red or discolored, hot, or itchy, or if green, yellow, or cloudy discharge drains out. Ask your HysterSisters. 2019. 121 0 obj <> endobj The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Reducing postsurgical wound complications: A critical review. and Is Fixing Pediatric Nail Bed Injuries With Medical Adhesives as Effective as Suturing? Acad. Medicinal use of cyanoacrylate adhesives before FDA approval dates to the Vietnam War where field surgeons regularly used the formulation to quickly stop haemorrhage from skin wounds [10]. This polymerization is an exothermic reaction which may release significant heat [7]. 2023 Healthline Media LLC. Singer, A. J., Kinariwala, M., Lirov, R. & Thode, H. C. Jr. Habib, Nazia Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Anyone ever had allergic reaction to Enjuvia? I have hypothyroidism and take armour and metformin . 2-octyl cyanoacrylate; Dermabond; allergic contact dermatitis; ethyl cyanoacrylate; gel nails, (meth)acrylate; tissue adhesive. Polymerized cyanoacrylate degrades into substances such as cyanoacetate and formaldehyde that may produce skin inflammation if accumulated in surrounding tissue [13]. Unable to load your collection due to an error, Unable to load your delegates due to an error. Surgiseal and LiquiBand were applied to two thin layers with a drying time of 30 to 60s between layers to enable polymerization, and Dermabond Prineo was applied with the same process to a mesh. All rights reserved. Unlike 2-octyl cyanoacrylate, to the best of our knowledge, there has been no study on the incidence of ACD in n-butyl cyanoacrylate topical skin adhesives. Bone Jt. : A Review of the Literature. Dumville JC, Coulthard P, Worthington HV, et al. We explain possible remedies and types. The Neuroanatomy of Poststroke Subjective Sensory Hypersensitivity. Intraoperatively, Veress needle entry was made into the abdominal cavity and a 5 mm trocar with scope was placed to visualize the abdominal cavity. In vivo study of wound bursting strength and compliance of topical skin adhesives. 2021. Diffuse Cutaneous Allergic Reaction to Dermabond, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, Department of Physical Medicine and Rehabilitation, Thomas Jefferson University Hospital, Philadelphia, PennsylvaniaUSA, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, https://doi.org/10.1017/S1049023X14001010, Get access to the full version of this content by using one of the access options below. Cell Mol. Med. 0000098852 00000 n Dermal Hypersensitivity Reaction to Semaglutide: Two Case Reports. Surg. Technol. for this article. 16, 146150 (2006). The clinical characteristics of patients with allergic contact dermatitis (ACD) due to a skin adhesive containing 2-octyl cyanoacrylate, Dermabond, have not yet been elucidated. Percutan Tech. Clipboard, Search History, and several other advanced features are temporarily unavailable. PubMedGoogle Scholar. From the Division of Plastic Surgery, Robert Wood Johnson Medical School, New Brunswick, NJ. Afifi, Ahmed M. Injury 49, 19421946 (2018). Do they pose any danger to your health? 0000004792 00000 n This article describes a severe allergic reaction to Dermabond following breast augmentation/mastopexy. Plast. OA Texts journals are led by prominent Inflamed skin should be treated with hydrocortisone 1% applied topically two to four times per day until reaction abates. It. 2021GR145), 1167 patients who underwent skin closure with topical skin adhesives in our institution between April 2017 and February 2021 were investigated for study eligibility. Clinical photograph of a patient showing well-demarcated pruritic eczematous eruption, papules, and vesicles that developed in the skin area to which topical skin adhesive was applied. H\n@C 3,9Fa} c/vMDZ$qvoxnS1>[yos,:? Dermatitis 25 , 99-100 (2014). Publication types Case Reports MeSH terms Breast Implantation / adverse effects B, Two months after breast augmentation/mastopexy and resolution of her allergic reaction to Dermabond. xref If allergic dermatitis is the diagnosis, avoiding the irritant is the first line of defense. However, despite their long period of usage, their fundamental shortcomings, such as time-consuming nature, cosmetic issues, and the need for removal are still unresolved4,5,6. 0000014217 00000 n Usatine, R. P. & Riojas, M. Diagnosis and management of contact dermatitis. Rabah, Sari Monzer This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department. Prog. If the patients presented with a skin eruption that was not visible in ordinary cases, they were referred to a dermatologist for the diagnosis of ACD. Dermatitis 2016; 27 (2):75. Orthop. Although cyanoacrylates traditionally have been associated with low rates of sensitization, allergic contact dermatitis (ACD) to Dermabond products is being increasingly reported after. The variables used to determine the risk factors of ACD to topical skin adhesives were retrieved from electronic medical records. We avoid using tertiary references. Ronis ML, Harwich JD, Fung R, Dellavecchia M (1984) Review of cyanoacrylate tissue glues with emphasis on their otorhinolaryngological applications. Gonzalo-Garijo MA, Perez-Calderon R, Perez-Rangel I, Sanchez-Vega S, Constantino JA (2009) Contact dermatitis after orthopaedic surgery. Given the case history, the patient was likely sensitized to Dermabond from prolonged exposure to embedded Dermabond from a previous procedure. The rash should go away completely within a few weeks. Pediatr. The risk factors for ACD were identified using logistic regression analysis of odds ratios. 15, 689695 (2004). 0000059447 00000 n 0000105281 00000 n TREK-1 and TREK-2 knockout mice are not resistant to halothane or isoflurane. 2018. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. However, considering that the mechanism of type IV hypersensitivity does not differ depending on the body part and the used site was not a factor affecting the occurrence of the ACD17,22, it is judged that the bias in the study population will not affect the generalization of the study results. Confirmatory allergic patch testing performed three years after initial reaction was positive for ethyl cyanoacrylate. Zwemer, Catherine A 36-year-old white woman on postoperative day four. Bethesda, MD 20894, Web Policies Past medical history is significant for stage 0 DCIS, chronic hypertension and migraine headache. and JavaScript. You can learn more about how we ensure our content is accurate and current by reading our. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. See additional information. dermabond - allergic reaction Need Answers? She also took a 20-mg oral dose of prednisolone. Cook, Kevin A. 0000010096 00000 n Despite these advantages and convenience in use, several recent studies have reported complications associated with its use; these are being increasingly reported as the use of the material has steadily increased. Epub 2021 Dec 16. Over several decades, skin staples and sutures have been regarded as a common method for skin closure. 0000010011 00000 n To address this issue, we reviewed 1027 patients who underwent skin closure with 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives to investigate the incidence and risk factors of ACD to topical skin adhesives. Shupak, Raymond P. Acad. 0000000016 00000 n In addition, the sutureless closure has become a marketing tool for surgeons. Sunaga, Ataru 2019 Sep/Oct;30(5):314-322. doi: 10.1097/DER.0000000000000514. and 2002. All the study protocol were conducted in accordance with the relevant guidelines and regulations (STROBE guidelines)18. Thakkar, Punam G. RicciJA, ParekhNN, DesaiNS. & Pawlik, T. M. STROBE reporting guidelines for observational studies. Allergic contact dermatitis: Epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. In this retrospective study, 577 patch tested patients were included. 39, 12831289 (2018). hasContentIssue false, Correspondence: Joseph A. Ricci, MD Division of Plastic Surgery Brigham and Women's Hospital 75 Francis Street Boston, Massachusetts 02115 USA E-mail, Copyright World Association for Disaster and Emergency Medicine 2014.