Pharmacology & Therapeutics, May 2011; vol 130: pp 157-176. As shown in Figure 5, kidney PGC-1 was slightly increased in HFD mice compared with LFD mice, and it was further increased after six-month BL153 treatment at indicated doses (Figure 5(a)). Spoto B, Mattace-Raso F, Sijbrands E, et al. Though more rigorous human studies are needed, the polyphenol shows promise as an anticancer therapy in humans (20). As a well-known insulin resistance regulator, PGC-1 also has been reported to exert anti-inflammation effects by multiple mechanisms [2729]. Avoid keeping the ground around the magnolia constantly moist. It is also used to regulate gastrointestinal motility and is found in herbal formulas such as Ma Zi Ren Wan. Stress is defined as a state of mental or emotional strain caused by adverse circumstances. In the present study, we explored the therapeutic potential of a <i>magnolia</i> extract (BL153 . Animal studies show the anti-inflammatory and antioxidant properties of magnolia bark protect kidneys from high-fat diet-induced damage. This can make it unsafe for you to drive a vehicle or use heavy machinery. In one study, a treatment containing magnolia extract was linked to less anxiety in menopausal women. Magnolia bark can also be toxic and has been linked to kidney disease and permanent kidney failure. Magnolias have always been highly sought-after trees in the yard. Several previous studies about magnolia extract obtained similar conclusions. Wounds on the trunk in which there is rotten wood. Some early case studies of women undergoing weight management treatment reported kidney issues caused due to a preparation containing magnolia bark, however, further analysis revealed possible contamination, adulteration, or use of substandard products as the cause of kidney damage. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Western blot assay was performed as previously reported [37]. n = 5; *P < 0.05 versus LFD group; # HK II expression was detected by western blot assay. Cortisol is the primary stress hormone in your body. PMID: 16454147. In human bladder cancer cells, it induced p27KIP1-mediated G2/M-phase cell cycle arrest to activate the extracellular signal-regulated kinase pathway(11), and decreased binding of transcription factor NF-kB to DNA to inhibit MMP9 expression(12). ", J Zhejiang Univ Sci B: "Biological activity and toxicity of the Chinese herbMagnolia officinalis.". A 24-week study in 89 menopausal women experiencing symptoms of sleep and mood alterations were given a supplement containing 60 mg of magnolia bark extract and 50 mg of magnesium daily. Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. Is magnolia bark a benzodiazepine? [Fact Checked!] 2012 Mar 19;9:57. doi: 10.1186/1742-2094-9-57. It is a disease that quite severely spoils the appearance of the bright green leaves of magnolia trees. Kalman DS, Feldman S, Feldman R, Schwartz HI, Krieger DR, Garrison R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. How kidneys work. Briefly, protein was separated on 10% SDS-PAGE gels and transferred to nitrocellulose membranes (Bio-Rad, Hercules, CA). In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. Magnolia Officinalis - an overview | ScienceDirect Topics For example, 4-O-methylhonokiol, a novel compound isolated from Magnolia officinalis, prevents the development and progression of Alzheimer's disease by improving oxidative stress through a p38 MAPK-dependent pathway [25]. If you notice it in time and treat it, nothing terrible will happen. Once worked as a pivotal mediator in glycolysis by catalyzing the phosphorylation of glucose to generate glucose 6-phosphate [32], HK II has emerged to play a role in oxidative stress recently [33, 34]. The bark then undergoes a process of drying and boiling before its infused into a tincture for oral consumption. They have also been evaluated for their anticancer potential. Although remarkably elevated in HFD-fed mice at the end of experiment, ACR was significantly reduced after administration with BL153 at the dose of 5mg/kg or 10mg/kg for six months (Figure 1). Side Effects Of Magnolia Bark - Good Health All In the present study, we explored the therapeutic potential of a magnolia extract (BL153) for. Wetwood is a disease that affects the trunk and branches of magnolia trees. Then turn off the gas. J Int Soc Sports Nutr. Chewing gum with magnolia bark extract may promote better breath and gum health. ", Molecular Nutrition and Food Research: "Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice. 13 Exciting Health Benefits of Magnolia Bark - OAWHealth Inhibition of melanogenesis and antioxidant properties of magnolia grandiflora L. Flower extract. However, no effective therapeutic method for obesity-associated kidney disease is available. Clark AM, El-Feraly FS, Li WS. 2007 Nov 14;55(23):9465-9. doi: 10.1021/jf072122h. BL153 ameliorated obesity-induced renal oxidative stress. Throw it all in the trash or burn it. However, the supplement used in these studies contained compounds other than magnolia bark. Not enough is known to rate the safety of topical supplements with Magnolia Bark applied to the skin. More than 200 types of magnolia trees exist worldwide. People who use benzodiazepine may use magnolia bark as a natural sedative. Weisinger JR, Kempson RL, Eldridge FL, Swenson RS. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. Honokiol is a potent scavenger of superoxide and peroxyl radicals. Evidence in studies with menopausal women suggests that Magnolia Bark extract may decrease the frequency and severity of menopause symptoms including: Menopausal women taking Magnolia Supplements may experience some side effects including: One study treated menopause patients with a dosage of one 60mg tablet of Magnolia Bark extract daily for 24 weeks. Phytotherapy has been used for human disease as an alternative or complement to allopathic medicines for several centuries [8, 9]. Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice. Design, Formulation and in vivo Evaluation of Novel Honokiol-Loaded PEGylated PLGA Nanocapsules for Treatment of Breast Cancer. Accumulating evidence demonstrated that obesity is a risk factor for renal structural and functional changes, leading to the end-stage renal disease which imposes a heavy economic burden on the community. Based on these, we hypothesized that increasing HK II expression might be another mechanism underlying renoprotection by BL153 in obesity-induced kidney injury. Always disinfect tools when pruning. Then they begin to develop and destroy the tissues of the tree. Cui W, Bai Y, Luo P, Miao L, Cai L. Preventive and therapeutic effects of Mg132 by activating Nrf2-are signaling pathway on oxidative stress-induced cardiovascular and renal injury. FOIA Try to keep your magnolia tree undamaged. 2011 Feb;63(1):11-7. Male C57/BL6/J mice at 8 weeks of age were purchased from the Jackson Laboratory and housed in the University of Louisville Research Resources Center at 22C with a 12-hour light/dark cycle. Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-, Lee YK, Choi IS, Ban JO, et al. The bark, leaves, and flowers of the houpo magnolia tree are used in traditional medicine to treat anxiety, depression, and more. However, Zhang et al. Kidney tissues were homogenized in RIPA buffer and total protein was extracted. Magnolia Extract (BL153) Ameliorates Kidney Damage in a High Fat Diet Hellstrm MK, Ramberg P. The effect of a dentifrice containing Magnolia extract on established plaque and gingivitis in man: a six-month clinical study. Two antiplatelet agents from Magnolia officinalis. The .gov means its official. Renal pathology was examined by using hematoxylin and eosin staining (b), and the arrows indicated glomerular enlargement and renal tubular epithelium damage. Magnolia bark may cause kidney failure after long-term use. Accessibility Phytomedicine. Medicinal uses Magnolia bark has been used to treat menstrual cramps, abdominal pain, abdominal bloating and gas, nausea, and indigestion. found that TNF- treatment leads to insulin resistance upon glucose uptake, glucose transporter 4 translocation, and insulin signaling [21]. In murine models, honokiol enhanced low-dose docetaxel treatment against prostate cancer growth and bone metastasis(37), and reduced breast tumor growth biomarkers(48). Magnolia barks effects on sleep appear to be closely connected to the activity of the GABA(A) receptors in the central nervous system. Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors. Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of, Yu S-X, Yan R-Y, Liang R-X, Wang W, Yang B. Bioactive polar compounds from stem bark of. On the other hand, overexpression of HK II is involved in cancer cell proliferation and migration [35]. PMID: 24062717; PMCID: PMC3769637. 2017 Mar.;18(3):194-214. One study found that breath mints made with magnolia bark helped kill the oral bacteria that causes bad breath and tooth decay within 30 minutes, suggesting that magnolia bark in gum and mints may make visits to the dentist's office much more pleasant. Additional studies and research is required to establish a relationship between thyroid function and magnolia bark usage if any. Mailloux RJ, Dumouchel T, Aguer C, Dekemp R, Beanlands R, Harper M-E. Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration. Polyphenols, such as those found in magnolia bark, have been suggested as a potential therapy to combat the side effects of oxidative stress and inflammation (12). Ensure good air movement around the crown. Regulation of Mucin 1 and multidrug resistance protein 1 by honokiol enhances the efficacy of doxorubicin-mediated growth suppression in mammary carcinoma cells. Kim YJ, Choi MS, Cha BY, et al. Seizures or coma in severe cases. Magnolia Bark: Benefits, Usage, and Side Effects - Healthline The latter were blocked with 5% milk, followed by incubation with the following antibodies: TNF-, PGC-1 (Abcam, Cambridge, MA), PAI-1 (BD Bioscience, San Jose, CA), 3-NT (Millipore, Billerica, MA), 4-HNE (Alpha Diagnostic International, San Antonio, TX), HK II, -actin, and NQO1 (SantaCruz Biotechnology, Santa Cruz, CA). 2010;33(3):427-31. doi: 10.1248/bpb.33.427. Front Neurol. Statistical significance was considered as P < 0.05. The site is secure. As a result, the leaves above the wound begin to turn yellow and fall off. Antitumor activity also occurred via MMP9 inhibition through the NF-kB pathway in breast cancer cells(19) and through AMPK activation in colorectal cancer cells(18). Cissus quadrangularis: Uses, Benefits, Side Effects, and Dosage, Galangal Root: Benefits, Uses, and Side Effects. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. and transmitted securely. Novel histone deacetylase inhibitors derived from. After the studies, researchers found that the treatment group did not gain any weight as opposed to the placebo group. (1) LFD + 5mg/kg group: mice were fed an LFD and supplemented with BL153 at the dose of 5mg/kg; (2) LFD group: mice were fed an LFD and supplemented with 0.5% ethanol; (3) HFD group: mice were fed an HFD and supplemented with 0.5% ethanol; (4) HFD + 2.5mg/kg group: mice were fed an HFD and supplemented with BL153 at the dose of 2.5mg/kg; (5) HFD + 5mg/kg group: mice were fed an HFD and supplemented with BL153 at the dose of 5mg/kg; and (6) HFD + 10mg/kg group: mice were fed an HFD and supplemented with BL153 at the dose of 10mg/kg. 1981 Aug;70(8):951-2. doi: 10.1002/jps.2600700833. This result is significant as high cortisol levels have been strongly linked to high blood pressure. Magnolia officinalis is a flowering herb that has been used in traditional Chinese medicine to treat anxiety, depression, stress, nervousness, and sleep-related problems. Given the contradictory nature of studies and the available information, more human studies and clinical trials are required to establish the effects of magnolia bark on kidneys. The supplement can be found at many online and retail stores. As an Amazon Associate, cesupplement.com earns commissions from qualifying purchases made through our links to Amazon. Magnolia bark extract has been tested in studies as an ingredient in chewing gum. Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation. 2008 Apr 1;32(3):715-25. doi: 10.1016/j.pnpbp.2007.11.020. Epub 2018 Jun 20. PMID: 22771461. Our data showed that BL153 administration did not affect HK II expression level in LFD group mice; moreover, BL153 administration in HFD group mice only increased HK II expression back to the normal level, even at a high dose (10mg/kg), indicating the safety of BL153, as illustrated in Figure 7. These effects were enough for an introduction as a cosmetic material in moisturizers and face washes to alleviate irritated skin or manage skin diseases such as acne and atopic dermatitis. Chronic kidney disease can progress to end-stage kidney failure, which is fatal without artificial filtering (dialysis) or a kidney transplant. Antitumor and antiangiogenic properties of honokiol are attributed to NF-kB inhibition and the consequent scavenging of reactive oxygen species(24). PDF Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes Skin rash has been reported with the use of cosmetics containing magnolia bark extract. Epub 2008 Jun 26. PMID: 29925102. Greenberg, M. Journal of Agricultural and Food Chemistry, Nov. 14, 2007; vol 55: pp 9465-9469. A chemical in magnolia reduced damage in the. 2016 Dec 4;193:657-662. doi: 10.1016/j.jep.2016.10.016. Walker JM, Maitra A, Walker J, et al. If the gall grows around the trunk, the sap flow can be interrupted and the tree will die. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Magnolia Benefits & Information (Magnolia Officinalis) - Herbwisdom More than 250 ingredients can be found in the bark, flowers and leaves of the Magnolia, but two of the main compounds used in dietary supplements are magnolol and honokiol. Magnolia: Uses and Risks - WebMD National Library of Medicine The flower and bark of Magnolia have been widely used as traditional herbal remedy for various disorders such as headache, fever, anxiety, diarrhea, stroke, and asthma. Several distinct pathways through which insulin resistance and hyperinsulinemia lead to renal damage have been reported by overwhelming background studies, such as insulin-like growth factor 1 upregulation [4] and renin-angiotensin system activation [5]. Therefore, the effects cannot be credited to the tree bark alone. (PDF) Herbs for Relieving Chronic Renal Failure - ResearchGate Identification of, Kuo WL, Chung CY, Hwang TL, Chen JJ. Int J Mol Sci. If the infestation is on the branch, cut it off below the affected area. The only chemical that can control this disease is a copper fungicide. Epub 2007 Nov 28. Int J Dent Hyg. Ong CP, Lee WL, Tang YQ, Yap WH. 2019 Dec 22;12(1):48. doi: 10.3390/cancers12010048. kidney - English-Spanish Dictionary - WordReference.com P < 0.05 versus HFD group. American Chemical Society. The bark possesses calming, antimicrobial, anti-inflammatory, and antioxidant effects. This will help them manage your care and keep you safe. As a result, their appearance is severely damaged, although it is rarely fatal to the tree. Careers, Unable to load your collection due to an error. PMID: 17949053. 19 Magnolia Bark Medicinal Uses (Kidney Failure Side Effects? Biochem Pharmacol. Since here the treatment is longer than that, we also included one low dose of BL153 at 2.5mg/kg. I want to help other fitness enthusiasts in their journey to a healthier lifestyle and avoid wasting their time on ineffective supplements the same way I did in the past. After that, accumulating evidence supported that obesity is an independent risk factor for renal structural and functional changes, leading to end-stage renal disease which brings the society a heavy economic burden [2, 3]. Magnolia bark may alter the effects of drugs that affect the functioning of the cytochrome P450 enzyme. Sweet Magnolia: Tree Bark Extract Fights Bad Breath And Tooth Decay. ScienceDaily. In animal models of prostate cancer with bone metastasis, honokiol induced apoptosis via caspase-3,-8, and -9 activation and poly (ADP-ribose) polymerase (PARP) cleavage(37). Data were collected from five animals for each group and presented as means SD. Sarrica A, Kirika N, Romeo M, Salmona M, Diomede L. Safety and Toxicology of Magnolol and Honokiol. Prog Neuropsychopharmacol Biol Psychiatry. Epub 2017 Aug 17. 5) and concentrated under reduced pressure to obtain viscous dark-brown residue (360g, BL153). One type Magnolia officinalis is commonly called the houpo magnolia, or sometimes simply magnolia bark.. And the quality and active ingredients in supplements may vary widely from maker to maker. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. This makes it hard to set a standard dose. Furthermore, an animal study concluded that chronic treatment with magnolia bark extract has an antihypertensive effect. The soy isoflavones were more effective for hot flashes, vaginal dryness, nocturnal sweating, and palpitations [R, R]. Therefore, the current study was undertaken to study the effects of magnolia extract (BL153) on renal injury in an HFD-induced obesity mouse model. Vazquez-Carballo A, Ceperuelo-Mallafre V, Chacon MR, et al. The houpo magnolia tree is native to China, where it has been used for thousands of years as a supplement in traditional Chinese medicine. However, these studies used magnolia in combination with other compounds. Today, magnolia bark extract is readily available in pill form. BL153 administration in an obese state attenuates kidney inflammation and oxidative stress, leading to improved renal pathological and functional alterations. 2005 - 2023 WebMD LLC, an Internet Brands company. Lee Y-J, Lee YM, Lee C-K, Jung JK, Han SB, Hong JT. Anti-bacterial: helps against acne and itching. In some studies, a treatment that contained magnolia lessened pain and constipation in people with a type of indigestion. Chronic kidney disease - Symptoms and causes - Mayo Clinic Huang HC, Hsieh WY, Niu YL, Chang TM. Diabetes mellitus is a chronic metabolic disease characterized by disturbances in carbohydrate, protein, and lipid metabolism, often accompanied by oxidative stress. Kidney weight was normalized by tibia length (a). All information in this website is for informational and/or entertainment purposes only, and is not reviewed by any qualified medical professional, and it is not intended to be a substitute for professional medical advice. Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). This makes sense, as its known that GABA(A) receptor activity is closely associated with sleep (29). Agrobacterium tumefaciens is a bacterium that causes a disease called crown gall. Epub 2016 Oct 6. Repeat the spraying in two weeks. Taken together, the present study declares that BL153 administration may be a novel approach for renoprotection in obesity individuals. Received 2013 Sep 19; Revised 2013 Oct 31; Accepted 2013 Nov 6. The ethanol extract of M. officinalis (BL153) was analyzed by HPLC to ensure mainly that it is containing 14.8% of 4-O-methylhonokiol, 14.2% of honokiol, and 12.0% of magnolol, which were in agreement with previously published data [42]. There are several types of bacteria that cause this disease. Furthermore, it is frequently associated with other inflammatory disease such as diabetes and cardiovascular disorders. To make the tea use dry petals available commercially or collect petals from an organically grown magnolia tree. Collect all of the fallen leaves around the magnolia. Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. Water the magnolia with liquid fertilizer to give it the strength to fight the disease. Planta Med. After filtration through the 400-mesh filter cloth, the filtrate was filtered again through filter paper (Whatman, no. A proposed mechanism by which BL153 attenuates kidney damage during obesity is illustrated. As a result, light gray spots appear on the leaf blade about half an inch across. Magnolol in Magnolia Bark will stimulate corticosterone secretion which will likely cause problems if you are using steroid medication. Usually in spring, when the weather is warm and humid, the pathogens settle on young leaves and begin to germinate. Teng CM, Chen CC, Ko FN, Lee LG, Huang TF, Chen YP, Hsu HY. 2013 Aug 7;10(1):37. doi: 10.1186/1550-2783-10-37. Magnolias are also susceptible to nectria canker, a bacterial infection that causes sunken, discolored areas of bark. As a library, NLM provides access to scientific literature. Another candidate molecule is HK II. Lee J, Jung E, Park J, Jung K, Lee S, Hong S, Park J, Park E, Kim J, Park S, Park D. Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling. Other interactions: Taking magnolia bark with blood thinners, including aspirin, is not recommended. The nephrotic syndrome: a complication of massive obesity. Chen CR, Zhou XZ, Luo YJ, Huang ZL, Urade Y, Qu WM. The bark, leaves, and flower buds of the Magnolia tree have many medicinal uses that have been studied in medical literature, including the following: In the video below, Dr. Lindsey talks about the benefits of Magnolia Bark Extract: This is our recommended Magnolia supplement (Amazons Choice): The following are some side effects of magnolia bark: These side effects are rare and magnolia bark is safe for most adults for short-term use for up to 1 year. Severe canker infections can cause plant death. A similar study in more than 600 menopausal women found that consuming a magnolia bark supplement daily for 12 weeks relieved symptoms of insomnia, irritability, and anxiety (32). Therapeutic applications of compounds in the Magnolia family. Up till now, more than 250 kinds of ingredients have been isolated from the cones, bark, and leaves of the Magnolia genus, such as magnolol, honokiol, 4-O-methylhonokiol, and obovatol [10]. Though the use of magnolia bark is common in traditional Chinese medicine, you may wonder what current research says about the tree bark. Irregular heartbeat. PMID: 7310672. In the lab trails, magnolia bark extract killed 100% of the bad odor-causing bacteria. 2012 Nov;63(6):1191-9. doi: 10.1016/j.neuropharm.2012.06.031. Kidney-shaped tray, kidney dish kidney/Renal failure - medical magnolia bark, white willow bark, white kidney bean - medical non cancerous mass in a kidney with a lesion in the middle - medical Only kidney present loss of tissue - medical pass a kidney stone more. Nausea. Further, magnolia bark has a well-established safety profile for short-term use. Review Article Herbal medicines and chronic kidney disease Spray the wound with copper fungicide and when it is dry, spray again with alcohol. Currently, there are no official recommendations for magnolia bark dosage. Show transcript for video How kidneys work. Taking magnolia bark along with drugs that promote sleep or treat. Besides anti-inflammation properties, Magnolia extract has also been found to take part in ameliorating oxidative stress through different pathways. A second study of the same magnolia and phellodendron bark extract in 56 adults observed that consuming 500 mg of the extract per day resulted in significantly lower cortisol levels and improved mood (25). Once cool, place the vessel overnight in a refrigerator allowing further extraction of petals. Epub 2013 Aug 23. Introducing the aspect of non-pharmacological treatment of diabetes . Zhao X, Li F, Sun W, Gao L, Kim KS, Kim KT, Cai L, Zhang Z, Zheng Y. Extracts of Magnolia Species-Induced Prevention of Diabetic Complications: A Brief Review. Zhang YK, Wu KC, Liu J, Klaassen CD. Expression of the thermogenic nuclear hormone receptor coactivator PGC-1. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of. 2008 Apr 21;7:11. doi: 10.1186/1475-2891-7-11. The medicinal use of this species is attributed to its different pharmacological effects, including anti-inflammation [11, 12] and antioxidative stress [13, 14]. However, how does magnolia extract modulate kidney inflammation and oxidative stress in obesity status is still unclear. Over time, they will turn dark brown. PGC-1 and NQO1 expression was detected by western blot assay. Magnolia Bark Extract Uses, Benefits & Dosage - Drugs.com Spray the leaves and petioles with an aqueous solution of copper fungicide. Zhang J, Chen Z, Huang X, Shi W, Zhang R, Chen M, Huang H, Wu L. Insights on the Multifunctional Activities of Magnolol. Last medically reviewed on April 7, 2020, Cissus quadrangularis is a plant that has long been used as a natural remedy to treat a wide variety of ailments. It is most dangerous for young trees. As mentioned, magnolia bark extract appears to have protective effects against many neurological conditions. 1The Second Hospital of Jilin University, Changchun 130041, China, 2The Kosair Children's Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA, 3School of Public Health, Jilin University, Changchun 130021, China, 4The First Hospital of Jilin University, Changchun 130021, China, 5Bioland Biotec Co., Ltd., Zhangjiang Modern Medical Device Park, Pudong, Shanghai 201201, China, 6Bioland R&D Center, 59 Songjeongni 2-gil, Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea. All rights reserved. Take care not to damage any living tissue. The study suggests that magnolia bark protects kidneys from oxidative stress, maintains the oxidative capacity of cells, and stabilizes the structure of epithelial cells during cancer treatment. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Cracks and growths on the trunk and branches. On the other hand, Magnolia bark offers short-term protection to kidneys against the toxicity induced by anticancer treatment. Risks. The fat-mass and obesity-associated gene (Fto) predicts mortality in chronic kidney disease of various severity. However, all these structure alterations were alleviated after six months of BL153 treatment at a dose of 5mg/kg or 10mg/kg (Figure 2). The polyphenols in magnolia bark honokiol and magnolol have been found to help induce and improve sleep. Some studies suggest it has anti-allergy effects. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. 2017 Nov;43(6):760-769. doi: 10.1002/biof.1385. And use caution if you take medicine to help you sleep or lessen your anxiety. This article reviews the, Sorrel, which refers to both a leafy green plant and its fruit, is known for its tart taste and powerful health benefits. In addition, some research -- in humans and animals -- suggests magnolia may also be useful in these ways: Some research has suggested some other possible benefits for magnolia: It might also help treat or prevent: Supplement makers may suggest varying amounts of their product for different purposes. This suggests that it has potential as a therapeutic agent for neurodegenerative diseases like Alzheimers. A study in mice found a magnolol dose of 2.30.9 mg per pound (525 mg per kg) of body weight significantly decreased sleep latency, or the amount of time it takes to fall asleep (27).