Giants 24, Chargers 23 -- Jordan Raanan, The Cardinals are 0-2 this season against NFC teams not in their division, but the biggest question mark will be whether the Cardinals can keep Carson Palmer on his feet. What to know for fantasy: Pierce has more than 100 scrimmage yards and a rushing score in consecutive games. Here are some lines that could change after this week's slate concludes. He is seeing the most targets per route run (32.4%) among wide receivers this season. See Week 5 rankings. Moody's pick: Eagles 30, Cardinals 17 Stat to know: Jared Goff is tied for the lead in passing touchdowns with 11. The Cardinals have allowed a league-high 20 sacks; the Bengals are right behind them at 19. It sounds crazy, but the Jets will win their third straight game. The Carolina Panthers, with the No. Read more. Why Lions GM is getting high praise Betting nugget: Minnesota is 22-10-1 ATS after a loss under Mike Zimmer. -- DJ Bien-Aime. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates . FPI prediction: LA, 65.1% (by an average of 4.7 points), Matchup must-reads: Jerry Jones: An 'injustice' not to give coach McCarthy credit Police report filed in Wagner tackle Cowboys D reaching elite levels of legendary Doomsday Defense? ET | ESPN/ESPN App Stat to know: JuJu Smith-Schuster's 15 receiving yards against the Bengals were the fewest he has had in a regular-season game in which he registered at least one reception. The offense remains a question mark, however, and could be without starting left tackle Rees Odhiambo because of a chest injury. Rams 23, Seahawks 20 -- Alden Gonzalez, The Ravens catch a break with EJ Manuel starting at quarterback for the injured Derek Carr. Stat to know: Chargers receiver Keenan Allen leads the NFL with 452 receiving yards, and he is the only player with more than 400. Additionally, ESPN Stats & Information research provides a stat to know for each game, and the Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. Including playoffs, Rodgers has thrown 29 touchdown passes with just eight interceptions in 15 games. ARI-CIN | DEN-LAC | GB-DAL They won't do anything to change that with a big win over the Giants. That was a reminder that their defense remains one of the NFL's best. -- Josh Weinfuss. Everything you want to know is here in one spot to help you get ready for a loaded weekend of NFL football. 198 days ago NFL Week 4 of the 2022-23 NFL season has come to a close. Betting nugget: Last season, first-round quarterbacks making their first career starts went 0-5 ATS. Williams' pick: Chargers 27, Broncos 20 Our NFL Nation reporters bring us the biggest keys to every game and a bold prediction for each matchup. Full list of Mr. Irrelevants in NFL draft history: Is Brock Purdy already the best final pick? The 2023 NFL Draft continues today in Kansas City! . Washington's pass defense is allowing 259.8 yards per game, but 294 yards per game at home. -- Brooke Pryor. -- Jamison Hensley. -- Kevin Seifert, Bold prediction: Kirk Cousins will have another three-interception day against the Bears' defense, akin to the last time the Vikings played against Matt Eberflus in Indianapolis, where Cousins recorded a 15.7 passer rating and three picks. But let's put the bold in bold prediction. NFL Week 5 odds, picks: Cowboys roll against Giants in Dallas, Patriots This has the makings of another close loss. Matchup rating: 65.9 | Spread: KC -11 (56), What to watch for: The Chiefs' defense allows a touchdown or a field goal on an alarming 43% of their defensive possessions, 25th in the league. What to know for fantasy: When you see "Brady vs. Atlanta," you likely think about the Super Bowl comeback, but that's not going to help you. But the Chargers are the right opponent at the right time. -- Jenna Laine, Bold prediction: The Falcons, with no Cordarrelle Patterson and against a good run defense, will manage to once again top 150 rushing yards with Tyler Allgeier leading the way. Stat to know: The Titans have allowed a player to record six or more receptions in each of their four games this season. -- Lindsey Thiry. What to know for fantasy: Darnell Mooney hauled in 17 of 25 targets for 183 yards when playing the Vikings last season. Week 5 NFL game picks, schedule guide, fantasy football tips and - ESPN Stat to know: Chiefs running back LeSean McCoy has three scrimmage touchdowns this season, matching his total in 14 games last season. If the Jaguars have the same kind of issues along the defensive front they did last week, it'll be another long day. They have an NFL-best plus-eight turnover margin. The Steelers have allowed three touchdowns on passes that have traveled at least 25 yards in the air, tied for third worst in the NFL. That stat line would be worth 259.6 points, not much different from the 260.1 points that Allen produced last season. NFL Week 5 Early Odds, Picks & Predictions (2022) by Jason Radowitz | Sep, 29 2022 Before Week 4 begins, there's plenty of value with some Week 5 lines. -- Jeff Legwold. Cronin's pick: Giants 21, Vikings 17 See Week 5 rankings. Read more. 1-ranked run defense to power the Browns to their second win on Monday Night Football this season. What to know for fantasy: Dalvin Cook has rushed for a touchdown in all four weeks this season and has seen his reception total increase each week as he continues to make a bid as a top-tier fantasy RB. Quarterback Jacoby Brissett has led the Colts to more than 30 points in a game only once in 19 starts, and that was 31 points in his second start back in Week 3 of the 2017 season. Watch the latest episode, Bold prediction: Cleveland running back Nick Chubb rushes for more than 100 yards against San Francisco's No. These teams are evenly matched, so quarterback play could make the difference. FPI prediction: JAX, 71.8% (by an average of 6.6 points), Matchup must-reads: Texans release starting TE Pharaoh Brown After loss, the Jaguars look to rebound against AFC South How LSU and the SEC prepared Texans rookie Derek Stingley Jr. for the NFL Former Jaguars QB Blake Bortles says he 'quietly' retired, What to watch for: Things have not being going well for Baker Mayfield. The one thing that might help their offense is the return of running back Alvin Kamara, who said he's ready to roll this week. Lamb has been targeted 42 times with 23 catches for 288 yards. Additionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. Keim's pick: Patriots 27, Redskins 7 The versatile back is now on pace for 115 catches this season. -- Mike Triplett, Everything you need this week: Matchup rating: 42.5 | Spread: MIN -5.5 (43.5), What to watch for: How will Kirk Cousins perform vs. the Giants' 25th-ranked pass defense, which is allowing 279.5 yards per game. He had just 14 receptions for 174 yards and zero TDs in 11 games last season. Betting nugget: The past four times Jacksonville was a favorite, it lost the game outright, with three of those losses coming against Houston. That's not the attitude a winless team needs. San Francisco's defense had seven sacks and 17 quarterback pressures on Monday night against the Rams. See Week 5 rankings. The NFL reporter use his Twitter account to share insight about the league's upcoming 2023 schedule . Newton's pick: Panthers 21, Jaguars 17 Rams 24, Seahawks 23 -- Brady Henderson, The Rams are feeling really good about themselves, coming off a big road win against the Cowboys. What to know for fantasy: Through four weeks, there were 44 players with at least 25 carries. Weinfuss' pick: Cardinals 20, Bengals 17 The Bills and Steelers matchup, discussed in greater detail below, moved from Buffalo minus-8 to Buffalo minus-14, but a perhaps. NFL odds, Vegas lines, picks, spreads, bets, predictions for Week 5 Stat to know: The Patriots are looking to become the first team since the 1988 Browns and Dolphins to allow zero passing touchdowns in the first five games of the season. Read more. This scheme has not changed and is bolstered on the back end by Eddie Jackson, who leads the NFC in interceptions with three in four games. The answer is to be determined, Cruz expects Minshew will lead Jags over Allen's Panthers (1:17), Week 5 NFL game picks, schedule guide, fantasy football tips and more, Which NFL teams still have roster holes? Given the Colts' struggles protecting the quarterback (they've allowed 14 sacks, tied for fifth most in the league) and the Niners' ability to take advantage of porous offensive lines (nine sacks total against Seattle and Arizona), this would seem to be the type of game the 49ers can win. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. See Week 5 rankings. Plus, Antonio Brown is angry and wants the ball, which means he's due for a big game. NFL draft 2023: Biggest post-draft questions for all 32 teams - ESPN Because of the injuries in the Steelers' secondary, Josh Allen is primed to jump out to a big lead early and then let the ground attack go to work to run out the rest of the game. How have point spreads moved for Week 5 as Sunday approaches? ESPN researcher Kyle Soppe hands out helpful fantasy football intel, as well. The 2023 NFL draft wrapped up Saturday and through five rounds, 12 quarterbacks were selected -- the most in the common draft era. Dolphins 17, Titans 14 -- James Walker, The Chargers finished 1-3 on trips to the East Coast last season and are in the midst of a nine-game losing streak. Vikings 27, Bears 26 -- Jeff Dickerson, Cowboys' running game will be tested on Sunday (1:06), Week 5 NFL predictions: Scores for every game, Dolphins' Jaelan Phillips, teammates inspired by mentoring incarcerated teens, What adding Odell Beckham Jr. would mean for the New York Jets, Extending Vikings star Justin Jefferson: what it could cost, possible sticking points. Trevor Lawrence: Jaguars have confidence, motivation for 2023 season, Steelers work to keep playoff hopes, Mike Tomlin's streak alive, Las Vegas Raiders' defensive tackles key in allowing edge rushers Maxx Crosby, Chandler Jones to thrive, 'He's got all the help he needs': Trey Lance won't have to be savior for loaded San Francisco 49ers, Las Vegas Raiders running backs the 'heartbeat' of the new regime's offensive attack, Mac Jones, Patriots express confidence in 'new offense' despite growing pains, New York Giants likely to buck norm, make safety Xavier McKinney defensive playcaller, Tyquan Thornton shows signs he could end Patriots' early-round WR woes. What to know for fantasy: Pittsburgh's Diontae Johnson owns a 20.5% target share this season from Rudolph, up from his 9.7% rate with Ben Roethlisberger under center. Young is NFL-ready thanks to his fast . While he acquitted himself generally well in a tough spot when Mailata went down against the Jaguars on Sunday, Arizona should have some opportunities to affect the passer. Read more. They also have a good secondary, which already has five interceptions. NFL best bets and picks for Week 5: Take the 49ers and the points, and the Jets-Falcons over. Betting nugget: Carolina is 3-15 ATS in its past 18 games. The Bengals are allowing 8.6 yards per attempt, which is ideal for a team averaging 5.5 despite having Kyler Murray -- who has thrown for 300 yards in two of his first four games. He has had 11 passes batted down at the line of scrimmage, six more than any quarterback in the NFL this season.
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